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While Open Science practices are highly desirable to advance the credibility and accessibility of knowledge gained through research, they are not as common in clinical psychology as many might hope. This paper presents an overview of how to implement Open Science procedures in clinical psychology and psychotherapy research. We will address frequently encountered challenges and present different ways to deal with sensitive topics within the specific field. We present steps towards Open Science while planning a study, during data collection and preparation of a publication, and for the publication of results. Finally, we will show options for how to structure a whole research group in support of Open Science practices. With different types of actions – of varying degrees of complexity – you can continually move the field towards transparency and towards more Open Science. This will strengthen the credibility of clinical research, which could be essential for motivating patients to seek care, as well as for influencing investments in clinical interventions and psychological treatments.